To a large bowl, add the cream cheese, cream of chicken soup, sour cream, cottage cheese, garlic powder, onion powder, smoked paprika, and cayenne. Mix until creamy and smooth. Then add the shredded chicken and parsley and mix well.
Transfer the chicken mixture to a 23 x 33 cm (9 x 13-inch) baking dish, and sprinkle over the shredded cheddar and mozzarella cheese.
Crush the butter crackers into a medium bowl and add the melted butter. Mix well.
Top the casserole with the cracker topping and bake uncovered for 35-40 minutes or until golden and bubbly.